In vitro evaluation of polymeric nanoparticles with a fluorine core for drug delivery triggered by focused ultrasound

Polymeric nanoparticles are being intensively investigated as drug carriers. Their efficiency could be enhanced if the release can triggered using an external stimulus such ultrasound. This approach is possible current commercial apparatus that combine focused ultrasound with MRI to perform ultrasonic surgery. In this approach, made of a perfluoro-octyl bromide core and thick polymeric (PLGA-PEG) shell may represent suitable Indeed, their perfluorocarbon detectable by 19F MRI, while encapsulate drugs. However, applicability in ultrasound-triggered delivery remains proven. To do so, we used Nile red model measured its from spectrofluorometry. absence ultrasound, only small amount was (<5%). Insonations were performed controlled environment 1.1 MHz transducer emitting tone bursts for few minutes, whereas broadband hydrophone detect occurrence cavitation. inertial cavitation, less than 5% released. presence ranging 10% 100%, depending duty cycle, acoustic pressure, tank temperature (25 or 37 °C). Highest releases obtained cycles 25% at °C 50% 25 peak-to-peak pressure above 12.7 MPa. Electron microscopy light scattering measurements showed slight modification nanoparticle morphology high contents. The strong cavitation thus prerequisite induce these nanoparticles. Since lead many unwanted biological effects, not therapeutic application delivery.